A car bomb and two suicide bombers attacked the Sayeda Zeinab district, home to Syria's holiest Shia shrine, as representatives of Syria's government and its divided opposition began convening in Geneva in an attempt to start the first peace talks in two years.
Bombs kill 50, wound 100 near Syria Shia shrine
The Syrian state news agency SANA has put the death toll from the attack at more than 50.
The British-based Observatory, which monitors the war using contacts on the ground, said the attack had targeted a military bus carrying Shi'ite militiamen who were changing guard, and that 42 of the dead were fighters allied to the government.
The Lebanese Shia militant group Hezbollah and other Iraqi and Iranian militias have a strong presence in Sayeda Zeinab, which is a site of pilgrimage for Shias from Iran, Lebanon and other parts of the Muslim world.
Bloodbath in Syria: Car, suicide bombs kill 60 in Damascus
While much of the Syrian leadership is drawn from an offshoot of Shi'ite Islam, Islamic State espouses a radical version of Sunni Islam and considers other sects to be heretical.
The area witnessed heavy clashes in the first few years of the war, prompting the army and allied Shia militias to tighten security, notably with roadblocks.
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