The government in Islamabad reacted angrily to the attack on Hakimullah Mehsud, leader of the Pakistani Taliban on Friday, saying it would scuttle its peace talks with the group.
"There inevitably will be some tensions and occasional misunderstandings between our two countries," White House spokesperson Jay Carney said.
"We hope to continue to make progress in the relationship, and we continue to seek ways for our countries to cooperate on the entire range of shared interests that we have, from economic to security issues."
Carney would not confirm the drone strike that killed Mehsud, in line with normal practice in such attacks, but he said the Tehreek-e-Taliban Pakistan (TTP) leader had a long list of extremist credentials, including a failed bombing in Times Square, New York, in 2010.
Carney charged that Mehsud and other TPP leaders had "publicly vowed to continue targeting the United States and Americans."
Mehsud was also wanted in connection with the killings of seven Americans at a US base in Khost province, Afghanistan.
The suicide bomb attack was one of the CIA's deadliest days in decades, as five of the agency's anti-terror officers and two contractors were killed.
The killing of Mehsud came just over a week after Pakistani Prime Minister Nawaz Sharif asked President Barack Obama in Oval Office talks to stop drone strikes.
Pakistan's Interior Minister Chaudhry Nisar on Saturday accused Washington of sabotaging peace efforts with the drone strike on Mehsud.
Anti-American sentiment runs deep in Pakistan and drone strikes are hugely unpopular, with many criticizing them both for civilian deaths and as a violation of sovereignty.
While expressing public fury, partly for domestic political reasons, Pakistani leaders will have to carefully weigh how to respond to the drone attack and may be unwilling to again alienate Washington as they try to reheat the economy.
As Sharif visited the White House last month, the State Department announced the release of $1.6 billion in aid, including $1.38 billion for the country's powerful military.
The money had been frozen as relations plummeted amid a series of crises in 2011 and 2012 including the US raid to kill Osama bin Laden at his hideout in Pakistan -- carried out without Pakistani knowledge.
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@faizaan: Don't glorify Bhutto. He was the one responsible for the massacre of thousands in Bangladesh.
Drones have become lethal for the people of Pakistan. If US is threatened then its not the Pakistani nation which have to sacrifice the lives of its people. No doubt these incidents are deteriorating the relations between two countries and also becoming a source of trust deficit between the two nations. Obviously Pakistan wont go for negotiations to any other state while having sacrificing the lives of its people.. The issue has become crucial to get solved and also getting a hype in the international community. its a clear violation of human rights and also to the sovereignity of a state. USA has to be answerable.
@csmann: How about Kashmir? What Indians have to do with IK etc?
Thank You USA. We need another 150-200 'justice delivering drones' ASAP.
The question is why wasn't he killed for the last 4 years? It's too much of a 'coincidence' that he was killed a day before the talks were to start.
Guess China will compensate Pakistan for the assistance that is going to be in jeopardy thanks to IK support for terrorists.IK will make sure to go to china and twist their arm.And off course,the huge china market is open to exports from Pakistan.
Even though Zulfiqar Bhutto had his own demons, but at least he had a spine, as compared to the Prime Ministers that we have had since 1988( I admit to no sympathy for TTP, but for a Nuclear Armed country such lopsided balance of relations is pathetic)