
The Pak-Dutch duo beat their opponents 6-2, 6-3, in a match lasting under two hours.
Aisam-Rojer will face the famous American Bryan brothers in their semi-final draw.
Later on Wednesday, the American twins beat French duo Julien Benneteau and Nicolas Mahut 7-6, 7-6 in their quarter-final draw.
The last time when the American pair and Aisam-Rojer played against each other at the Cincinnati Masters, the latter lost 4-6, 6-4, 10-4 in the quarter-finals.
It is noteworthy that Aisam's last US Open encounter in 2010 against the brothers, was alongside Indian partner Rohan Bopanna in the final, which resulted in the 'Indo-Pak Express’ being beaten 7-6 (7/5), 7-6 (7/4).
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