The van was en route to Ahmedpur with 20 passengers onboard.
Near Shah Hussain Bypass, gas leaked from the CNG cylinder, setting the van on fire followed by a blast.
Three women and a three-year-old child died on the spot, while the eight injured passengers were rushed to the Khairpur hospital.
Earlier, due to a leakage of LPG cylinder, a man was deprived of his house and valuables worth Rs2 million were burnt to ashes in Tanda Village on Sunday.
The fire, according to the owner, engulfed the entire house, injuring him and burning down all his belongings. His wife managed to escape unhurt.
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