Pakistan has reacted with fury and cut off crucial supply routes to Nato-led forces in Afghanistan after Saturday's incident near a checkpoint in the eastern Afghan province of Kunar.
The chief of US Central Command appointed Brigadier General Stephen Clark, from Air Force Special Operations Command in Florida, as the investigating officer for the probe that will also include a Nato representative, officials said.
The governments of Afghanistan and Pakistan "will be invited to participate," Central Command said in a statement.
Central Command, which oversees US forces in the Middle East and Afghanistan, wanted to "include these government representatives to the maximum extent possible to determine what happened and preclude it from happening again."
The Nato-led International Security Assistance Force (ISAF) sent an initial assessment team over the weekend to the border to look into the incident.
Pakistan has charged the air strikes were unprovoked, while Afghan and Western officials reportedly say Pakistani forces opened fire first.
Before Saturday's attack, US military officers had been working to shore up cooperation with Pakistani forces along the Afghan border. Communication between units on the border virtually broke down in the aftermath of a US raid in May that killed al Qaeda chief Osama bin Laden at his Pakistani compound.
COMMENTS
Comments are moderated and generally will be posted if they are on-topic and not abusive.
For more information, please see our Comments FAQ