The incident occurred in the Kaado Kor area of the Yakka Ghund tehsil in Mohmand Agency. No casualties have been reported.
Sources said the school building was completely destroyed in the incident. The school belonged to tribal elder Malik Inayat.
Since the start of the military operation in Mohmand Agency, militants have blown up some 52 schools in the area.
Earlier in September, a primary school for girls was blown up in Kalam, the first such instance after Operation Rah-e-Raast concluded in the Swat Valley more than a year ago.
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