
It was unclear why the Israelis fired at the car as it approached the checkpoint on a road connecting West Bank cities and Jerusalem before dawn.
According to Palestinian medical workers, the man in his 40s who was shot dead and the two others were traveling to pray in Jerusalem.
A spokesman for Israel's border police, which is stationed at checkpoints in the area, could not be reached for immediate comment.
Israel captured the West Bank and East Jerusalem, land the Palestinians want for a future state, during a 1967 Middle East War in a move that has not won international recognition.
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