Doctors warn against misuse of new weight-loss drug

Amid a rapid rise in the use of Semaglutide for weight loss among Pakistani celebrities and well-known public figures, medical experts have warned that the drug's misuse, especially in higher-than-recommended doses, poses serious health risks, including pancreatitis, thyroid cancer, and severe gastrointestinal complications.

Speaking to The Express Tribune, general surgeons said that Semaglutide is a weekly injectable medication originally prescribed to patients with type-2 diabetes for controlling blood sugar and glucose levels. They explained that the drug slows stomach and intestinal movement, prolonging the feeling of fullness and reducing appetite - an effect that has made it increasingly attractive for weight loss.

Common side-effects of the medication include nausea, vomiting, abdominal pain, and diarrhea, while more serious complications may involve pancreatitis and thyroid-related issues. The surgeons stressed that despite being designed specifically for diabetes management, Semaglutide's use is growing quickly in Pakistan. Using it solely to shed a few kilograms, they warned, is irresponsible and potentially dangerous.

Dr Shehryar, a plastic surgeon at JPMC, confirmed that Semaglutide's use is rising particularly among celebrities and social figures, with several well-known actors having experienced rapid weight loss through the drug. However, he warned that while Semaglutide is effective, it carries side-effects and must only be used under strict medical supervision.

Many people, he warned, begin with high doses or inject it every second or third day - even though the recommended starting dosage is just 0.25 mg weekly. Such reckless use can lead to thyroid cancer, pancreatitis, gallstones, dehydration, mood disturbances, impaired vision, and worsening diabetic retinopathy.

Reduced food intake and dehydration also frequently result in physical weakness. Dr Shehryar urged the public to use Semaglutide only on a doctor's advice, with proper monitoring and dosage, to avoid serious long-term health consequences.

Professor Abdullah Muttaqi, President of the Pakistan Islamic Medical Association Sindh, said that Pakistan is witnessing the same trend as the rest of the world regarding Semaglutide use. The drug, he explained, slows gastric emptying, suppresses appetite, enhances insulin secretion, and lowers blood sugar levels - all of which contribute to weight reduction. However, potential side-effects include nosebleeds, throat swelling, breathing difficulties, pancreatitis, calcium deficiency, abdominal discomfort, and excessive weight loss. He added that healthier and safer alternatives for weight loss include maintaining a balanced diet, regular physical activity, adequate sleep, and proper hydration.