Police in the Peel region near Toronto said on Saturday one person was killed and four were transported to hospitals in the Toronto area "in various conditions" after a shooting.
Police said in a statement on Twitter they had no information on suspects in the shooting, adding that the homicide bureau would take over the investigation. There were no further details.
Local reports said the shooting took place inside Chicken Land, a family-run take-out restaurant in a small strip mall.
Earlier on Friday, the remains of 215 children, some as young as three years old, were found at the site of a former residential school for indigenous children, a discovery Canadian Prime Minister Justin Trudeau described as heartbreaking.
The children were students at the Kamloops Indian Residential School in British Columbia that closed in 1978, according to the Tk'emlúps te Secwépemc Nation, which said the remains were found with the help of a ground-penetrating radar specialist.
"We had a knowing in our community that we were able to verify," Tk'emlúps te Secwépemc Chief Rosanne Casimir said in a statement. "At this time, we have more questions than answers."
Canada's residential school system, which forcibly separated indigenous children from their families, constituted "cultural genocide," a six-year investigation into the now-defunct system found in 2015.
The report documented horrific physical abuse, rape, malnutrition and other atrocities suffered by many of the 150,000 children who attended the schools, typically run by Christian churches on behalf of Ottawa from the 1840s to the 1990s.
It found more than 4,100 children died while attending residential school. The deaths of the 215 children buried in the grounds of what was once Canada's largest residential school are believed to not have been included in that figure and appear to have been undocumented until the discovery.