Deputy commissioner Khuzdar confirmed the incident and said that the coaches were on their way to Karachi and were coming from Khuzdar, Quetta and Panjgur.
Frontier Corps and Levies reached the spot after the road accident and started rescue activities.
"The driver of the buse was killed in the accident along with other passengers. Women are also among the dead."
An emergency was declared in the local government hospital of Khuzdar.
26 perish in Hub bus fire sparked by crash
Earlier in January, at least 26 people died and 16 others sustained burn injuries after a passenger bus collided with an oil tanker in Hub, Balochistan.
The collision led to the bus catching fire, which burnt 21 people to death while 16 others jumped off the bus in an attempt to save their lives.
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