The explosion was carried out through an improvised explosive device planted in a motorcycle parked on the roadside, police said.
According to sources, a police vehicle deputed outside a mosque was also damaged in the blast.
The injured, which included both civilians and security officials, were shifted to a nearby hospital.
Police, Frontier Corps and other law enforcement forces arrived at the scene, cordoned off the area and launched a search operation to arrest the culprits.
The blast comes two days after a terrorist attack on Pearl Continental Hotel, Gwadar in which five people were martyred.
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