
"We can confirm 14 deaths," Andre Costa, security secretary for the state of Ceara - of which Fortaleza is the capital - told a press conference.
Seven of the victims were identified: three men, two women and two teenagers. Local newspaper O Povo reported eight women and six men were killed.
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A spokesperson from the Institut Jose Frota hospital told AFP six people, including a 12-year-old boy, had been rushed in for emergency care.
Authorities did not say exactly how many people were injured.
The shooting broke out at 1.30am when a group of armed men arrived in three vehicles at the Forro do Gago nightclub in Fortaleza's Cajazeiras neighborhood.
"It's a brutal scene, a massacre. Something you never see in Ceara," a police officer, who asked to remain anonymous, told news website G1.
Local media reported that the shootout was a clash between members of two rival drug trafficking gangs.
Officials however remained tight lipped. "The investigation is still ongoing," Costa said.
On January 7, a war between drug gangs already claimed four lives in the suburbs of Fortaleza.
Last year there was a record 5,114 murders in the state of Ceara, a 50 per cent rise from 2016.
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