The Swiss academic, an Oxford professor and conservative Islamic intellectual in France, has been accused of rape by two women after the Harvey Weinstein scandal unleashed a wave of sexual abuse accusations worldwide. Ramadan, 55, has furiously denied the accusations as a "campaign of lies launched by my adversaries".
"Rape," reads the caption on Charlie Hebdo's cover. "The defence of Tariq Ramadan."
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The provocative magazine suffered a deadly attack in 2015 after publishing cartoons of the Prophet Mohammed (pbuh).
Later Monday the Paris prosecutor's office opened a police enquiry into the death threat claim, a judicial source said. That enquiry will look into "written death threats" and "public glorification of an act of terrorism," the source said.
Laurent "Riss" Sourisseau, the magazine's editor, said the threats and hate mail had "never really stopped" after the January 2015 militant attack in which 12 people were gunned down at its offices.
"Sometimes there are peaks when we receive explicit death threats on social media -- this has been the case once again," he told Europe 1 radio.
"It's always difficult to know if these are serious threats or not, but as a principle, we take them seriously and press charges."
The shooting at Charlie Hebdo was claimed by al Qaeda, with the militants notably seeking to punish the staunchly atheist magazine for printing cartoons of the Prophet Mohammed (pbuh), forbidden in Islam.
Ready-to-use home-made explosives found in Paris suburb
The attack was the first in a wave of militants attacks in France over the past two years that have left more than 240 people dead.
Charlie Hebdo has continued to court controversy since the attack, notably with cartoons after the Barcelona attack and others that made light of an Italian earthquake that killed nearly 300 people.
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