The latest killings take the death toll to 12 since Wednesday morning. Six people were killed in Orangi Town, three in New Karachi and one each in Sabzi Mandi, Lyari and Gulistan-e-Jauhar.
The Muttahida Qaumi Movement (MQM) claimed that three of the dead were political workers of the party.
Police have arrested one of the alleged shooters, who was found injured, in the Orangi incident.
A woman was also killed by unidentified gunmen in Gulistan-e-Jauhar.
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