The Dragon capsule -- the only such vessel capable of returning research samples and other material to Earth -- remained docked with the ISS for nearly a month after delivering more than two tonnes of food, water and scientific equipment for NASA on February 23.
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Before its departure, the crew loaded the cargo ship with old equipment, waste and almost 4,000 pounds of research samples from experiments carried out in the station's condition of microgravity.
Released by the ISS's robot arm at 0900 GMT, the capsule undertook a more than six-hour journey back to Earth, landing off the coast of Mexico just before 1600 GMT, its final descent slowed by three giant parachutes.
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"Today we said goodbye to the #Dragon!" tweeted the French astronaut Thomas Pesquet, one of six crew members, who arrived on the ISS in November.
"She is taking part of us back to the ground with her - important scientific samples, some from the crew!"
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