Harden compiled 22 points, 11 assists and 11 rebounds, completing his triple with three assists in the final quarter as the Rockets pummelled the Nets.
Harden was one of six Houston players to make double figures as the Rockets bounced back from consecutive losses to Minnesota and Memphis.
Antetokounmpo show not enough to save Bucks
Eric Gordon drained four three-pointers and led Houston's scoring with 24 points while Trevor Ariza added 23 points.
Patrick Beverley and Montrezl Harrell weighed in with 16 points each while Ryan Anderson added 12 as the Rockets blew away a feeble Nets defense.
It was a 10th straight defeat for the Nets, who are now propping up the Eastern Conference standings with a dismal 8-32 record.
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Houston's win saw them improve to 32-11, leaving them third in the Western Conference standings behind Golden State and San Antonio.
Brooklyn's losing streak is the second time in the past year that they have lost 10 in a row.
Trevor Booker led the scoring for the Nets with 18 points while Randy Foye contributed 13.
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