The 29-year-old reigning Wimbledon and Olympic champion stormed to an impressive seventh win in 10 meetings against the 22nd-seeded Dimitrov.
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From the moment Murray broke for a 3-1 lead in the first set, on the back of a lung-busting 32-shot rally, the outcome of the Arthur Ashe Stadium clash was never in doubt.
For good measure, Murray sent down his fastest ever serve of 141mph (226.9 km/h) at the end of a set where he allowed Dimitrov just five points on his service. "I once hit a 145mph serve in San Jose but they recalibrated the machine the next day so it didn't count. Tonight was the first time I have gone above 140," said the 29-year-old. "It was lucky and I doubt I'll ever do it again."
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Dimitrov broke only once in the match in the fourth game of the second set, but it was a brief respite as Murray quickly reclaimed it before taking 10 of the next 12 games to seal the rout.
Dimitrov committed 43 unforced errors as Murray set up a last-eight clash with Japanese sixth seed Kei Nishikori, the 2014 runner-up who downed 37-year-old Ivo Karlovic 6-3, 6-4, 7-6 (7/4).
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