
After a hastily-convened meeting with Erdogan, Prime Minister Binali Yildirim said Ala had stepped down and would be replaced by Suleyman Soylu, the current labour and social security minister.
'Teammates' Qatar and Turkey assert post-coup ties
There was no official explanation for why Ala had quit and Turkish media said it was unexpected.
Yildirim thanked Ala "for his services."
The ministerial change follows a failed July 15 coup, which was blamed on supporters of US-based Muslim preacher Fethullah Gulen, an arch enemy of Erdogan.
The abortive putsch raised questions about intelligence failings which government officials have acknowledged.
Ala had served as interior minister for nearly three years. He also previously acted as undersecretary to Erdogan, when the president was prime minister.
Ceasefire holding between Turkey and Kurdish fighters in Syria
Ala leaves the post as the insurgency between Turkish security forces and militants from the outlawed Kurdistan Workers' Party (PKK) rages following the collapse of a two-year truce last summer.
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