The injured passengers are reportedly in critical condition.
The bus was travelling from Quetta to Karachi and the van was going to Sukkur from Nawabshah when the collision occurred.
Police said that the incident took place due to speeding.
Rescue workers arrived at the scene and the injured passengers were taken to a nearby hospital for medical assistance.
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very sad indeed, RIP, Why can't we allow such bad vehicles and over loaded trucks and containers on our poor road infratsturcture specially in that area of Sindh province.