Two people were killed and six injured in Lyari as rival groups clashed in the Gulistan colony. Police have identified the deceased as Saeed Jan and Mohammad Farooq.
Police have arrested eight people, who are now being held in custody. The injured have all been taken to hospital.
Shops and markets in the area have closed.
Two people were shot dead by unidentified gunmen in Ranchore Line.
In another shooting, one person was gunned down in Usmanabad area of Lyari by unidentified gunmen.
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