The six were shot dead after they allegedly crossed the border and opened fire, the report said quoting the Iranian Sistan-Baluchestan province border police.
Over 1,000 kilos (2,200 pounds) of opium and hashish were seized, the report said.
"After a number of drug traffickers... not only did not pay attention to the halt orders but started shooting, the Iranian border patrol returned fire," the police added.
The report came a day after Pakistani officials said that Iranian border guards shot dead at least six Pakistanis and wounded two others after they strayed across the border in a remote southwestern area of Pakistan.
Earlier this month, Pakistan deported three Iranian border guards after they were pardoned in court by the family of a man killed in a cross-border attack.
The guards were arrested on January 2 in southwestern Baluchistan province after allegedly crossing the border and shooting at a car, killing a Pakistani.
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