Yasin was taken into custody by Indian forces in February under the draconian Public Safety Law after which he was shifted to the notorious Tihar jail.
He was among 100 Kashmiris detained during overnight raids in the held territory in the aftermath of Pulwama incident.
In a video message to over 33,000 of her followers on Twitter, Mushaal said that: "My husband is moving towards a slow death... and I have no idea even where he is being kept."
Kashmiri rights activist slams New Delhi over 'unlawful' JKLF ban
She added that there are strong rumours that he has succumbed to illness in confinement.
"I appeal to the international community to raise its voice for my husband. He is a political prisoner and the face of the Kashmiri freedom struggle," she said.
The Kashmiri rights activist said that if anything happens to the JKLF chief then the Indian state would be held responsible.
"Every prisoner has the right to medical aid and I've said this so repeatedly that he needs to be immediately shifted to the intensive care unit of a hospital," she said.
Mushaal said that whenever she asked the Indian authorities of her husband's well-being all she received was silence, adding that, "I haven't spoken to him for the last five months."
My humble appeal to know about the condition and where abouts of my critically ill husband Mohammad Yasin Malik who is in Tihar death cell with strong rumours of his death. #KashmirIssue #KashmirUnderThreat pic.twitter.com/CYRSAYDgsP
— Mushaal Hussein Mullick (@MushaalMullick) August 4, 2019
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