International researchers analysing the impact of human activity, from fertiliser runoff to increased sea transport, on underwater ecosystems have mapped the dwindling zones considered pristine.
The bulk of remaining ocean wilderness, classed as "mostly free of human disturbance", was found in the Arctic and Antarctic, and around remote Pacific islands.
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"Improvements in shipping technology mean that even the most remote wilderness areas may come under threat in the future, including once ice-covered places that are now accessible because of climate change," said lead researcher Kendall Jones, from the University of Queensland.
Just five per cent of the wilderness areas are in protected zones, leaving the rest vulnerable, according to the study published in the journal Current Biology.
It called for greater international coordination to regulate the world's oceans, clamp down on overfishing, limit destructive ocean-mining and reduce sediment runoff.
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"Marine wilderness areas are home to unparallelled levels of life, holding massive abundances of species and high genetic diversity, giving them resilience to threats like climate change," said James Watson of the Wildlife Conservation Society.
"These areas are declining catastrophically, and protecting them must become a focus of multilateral environmental agreements.
If not, they will likely disappear within 50 years."
Last year, the United Nations began negotiating its first conservation treaty for the high seas, which would be a legally binding act governing the sustainable use of oceans outside national maritime boundaries.
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