"It's imperative to end this senseless human suffering now. Such targeting of innocent civilians and infrastructure must stop now," Panos Moumtzis, the UN's Regional Humanitarian Coordinator for the Syria Crisis said in a statement.
Two more civilians martyred as Indian aggression along LoC continues
Several days of bombardment on Eastern Ghouta, near Damascus, has killed hundreds of people, with one monitor of Syria's seven-year conflict saying that at least 77 people had died there on Monday alone.
Held by rebels since 2012, Eastern Ghouta is the last opposition pocket around Damascus and President Bashar al-Assad has dispatched reinforcements there in an apparent concerted effort to retake it.
Civil society condemns Indian aggression, unprovoked shelling
Moumtzis, whose organisation has repeatedly called for a cessation of fighting in Eastern Ghouta to allow in desperately needed food and medical aid, said the humanitarian situation in the rebel enclave was "spiralling out of control".
"The recent escalation of violence compounds an already precarious humanitarian situation for the 393,000 residents of East Ghouta, many of them internally displaced," he said.
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