The blast occurred on Monday night in San Isidro, Chilchotla, during preparations for a local festival next week.
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"A group of people lived in the house where the pyrotechnic material was stored for use in the festivities. A firework launched by someone outside (the house) fell on top of the fireworks, causing the explosion that knocked down the home," the government of Puebla said in a statement.
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Nine people were killed on the spot and three more died after being taken to nearby hospitals.
A series of massive explosions destroyed a fireworks market outside the Mexican capital in December, killing at least 35 people, injuring dozens and leaving the market a charred wasteland.
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