The exhibit, which runs March 17-June 11, includes films, paintings, photographs and sculptures from dozens of artists.
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One video installation, "A Very Long Line", created by a group of artists calling themselves Postcommodity, focuses on the long border between the United States and Mexico, an issue that has become politically polarising under US President Donald Trump.
Another work, a painting by Dana Schutz, focuses on Emmett Till, a 14-year-old black boy killed by two white men in a Mississippi Delta town in 1955.
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"It's a show about people's lives, about the issues that matter to them," said Scott Rothkopf, Deputy Director for Programmes at the museum.
"There's maybe not one theme, but certainly many people responding to the issues of the day with beauty, with grace, with metaphor," he added.
Watch the video of the exhibition here:
https://www.youtube.com/watch?v=rIxFSw_R9KA
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