Costa, the league's leading scorer, will miss the match after picking up his fifth booking last weekend and Batshuayi, who signed from Olympique de Marseille in the close season, has been tipped to get his first league start.
"When you have Diego in the team it is very hard to get a chance because he is playing so well and scoring goals, but I'm sure Michy is ready to take his opportunity because he is working hard every day," Matic told the London Evening Standard.
Conte impressed by reformed Diego Costa
Batshuayi has scored three times in 13 appearances for Chelsea, and Matic said the 23-year-old Belgian was an excellent understudy to Costa.
"Of course he has benefited from working with Costa. It was the same with me seven years ago (in Matic's first spell at Chelsea). It was very good for me to see how Frank Lampard played, how Michael Ballack played and Michael Essien," said Matic.
Conte urges leaders Chelsea to stay 'humble'
"So it is good for Michy and a good experience for him to see Diego's movement. He will have learned from watching and playing with Diego," he added.
Midfielder N'Golo Kante is also suspended, and Cesc Fabregas is expected to partner Matic in midfield for the league leaders when 10th-placed Bournemouth visit Stamford Bridge.
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