A security source later told Reuters no explosives had been found on the suspect.
The area around the City2 shopping centre, a major commercial hub in the middle of the Belgian capital, was sealed off, although the nearby metro station was still open.
Belgium charges three men with terrorism offences after overnight raids
A spokesperson for the Brussels prosecutor said the man was arrested at 5:30 a.m. and the army bomb disposal team was brought in to verify whether he was armed with explosives.
Television footage showed a large police presence in neighbouring streets.
Belgium's crisis centre, which coordinates security measures, said it was holding a meeting, with Prime Minister Charles Michel and Interior Minister Jan Jambon present, to discuss the incident.
Michel had been expected to appear on an early morning radio show before rushing off to the meeting.
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