The Yamaha rider crossed the line more than 10 seconds clear of his teammate Valentino Rossi, with Maverick Vinales on a Suzuki in third.
Lorenzo, who takes over the lead of the 2016 title race from Marc Marquez, was completing a perfect weekend in Le Mans after setting a record-breaking lap in qualifying on Saturday.
The defending world champion enjoyed a serene afternoon at the historic Bugatti circuit, avoiding mayhem behind with no fewer than eight riders failing to complete the 28 laps.
Lorenzo takes pole for French MotoGP
“This was a very important race, a great race for the championship,” said Lorenzo, who now leads Marquez by five points.
Marquez was one of those to crash, although he remounted his Honda to trail in at the rear of the pack.
From pole Lorenzo got off to a quick start to boss this fifth leg of the season.
The main winner at the start was Andrea Dovizioso, riding for Ducati, who surged from sixth on the grid to race in second, tracked by Marquez.
Masterful Rossi wins Spanish Grand Prix
Rossi, who set off from a season-lowest seventh after a mistake-strewn qualifying, triggered a huge roar from the crowd when he nipped past Marquez as the midway point of the race approached.
And the hugely popular Italian veteran soon only had his teammate Lorenzo ahead of him after overtaking Dovizioso.
With 13 laps to go Marquez and Dovizioso exited the scene in carbon copy crashes on turn seven, their bikes slipping from underneath them, to promote Vinales to third.
Championship leader Marquez manfully climbed back on board.
Grand Prix of the Americas: Fourth straight win for Marquez in Austin
Unaffected by all that drama Lorenzo was racing smoothly in front, well clear of Rossi, who was seeking to follow up his win in Spain a fortnight ago with 10 laps remaining.
Turn seven was to prove the undoing of a third rider when British Yamaha rider Bradley Smith slithered out of the race.
Published in The Express Tribune, May 9th, 2016.
Like Sports on Facebook, follow @ETribuneSports on Twitter to stay informed and join in the conversation.
COMMENTS
Comments are moderated and generally will be posted if they are on-topic and not abusive.
For more information, please see our Comments FAQ