Video footage provided by the National Police Agency showed the tiny pink pyjama-clad baby gently carried away in a blanket by helmeted rescuers from the rubble of the home.
Strong 6.4-magnitude quake hits southwestern Japan
The rescue of the eight-month old girl came in the Kumamoto prefectural town of Mashiki, the locale hardest hit by the 6.5-magnitude quake that struck Thursday night.
The girl whose name has not been released, reportedly did not suffer any injuries.
The child's mother, grandfather, grandmother, and older brother were in the living room and kitchen of the home as she slept in another room on the first floor when the quake shook the southern island of Kyushu, the Mainichi Shimbun daily reported.
The family members, who all managed to escape, tried to rescue the baby but the house collapsed, the paper said.
But a 50-member rescue team managed to pull her safely from the rubble around 3:45 am Friday (1845 GMT Thursday), Kyodo News reported.
The infant's rescue came as nine people were killed -- eight of them in Mashiki -- after dozens of aftershocks shook the area following the initial quake.
Strong quake in Japan kills at least nine, nuclear plants safe
Mashiki, a town with the population of about 35,000 people, is near the quake's epicentre.
People following news of the baby's ordeal shared their emotions on Twitter.
"I thought I'd cry," one user wrote. "Hope she is safely back to her mother. She had been a good girl for six hours!"
Another wrote: "So relieved to know the baby is safe. I cannot stop crying."
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