In a closely-contested men's field, Leonardo DiCaprio won for his lead role as a fur trapper seeking retribution in The Revenant while Matt Damon's astronaut stranded on Mars in The Martian won the comedy acting award.
Golden Globes 2016: The start of the red-carpet arms race
The Revenant also brought a directing prize for Alejandro Inarritu, who recalled the long arduous shoot in sub-zero temperatures. "Pain is temporary, but a film is forever," Inarritu said.
Jennifer Lawrence won best comedy movie actress for her portrayal of the Miracle Mop inventor in Joy, while Brie Larson, 26, beat veteran Cate Blanchett to take home her first major award for playing a young woman who is abducted and locked up for years in the movie drama Room.
Lesbian drama Carol and Wall Street comedy The Big Short, which had led nominations going into Sunday's ceremony, came home empty handed, as did admired Catholic Church sex abuse probe Spotlight.
Other popular winners includes Sylvester Stallone, 69, who received a standing ovation as best supporting film actor for reprising his iconic role as boxer Rocky Balboa in Creed, beating presumed frontrunner Mark Rylance for Bridge of Spies. "I want to thank my imaginary friend Rocky Balboa for being the best friend I ever had," Stallone said.
Red Carpet Roundup: 2015 Golden Globe Awards
Steve Jobs, a controversial look at the late Apple co-founder that floundered at the box office despite warm reviews, took home Golden Globes for supporting actress Kate Winslet, and screenwriter Aaron Sorkin.
The Golden Globes were handed out by the Hollywood Foreign Press Association at a glitzy Beverly Hills dinner packed with A-list celebrities.
Here's the complete list of winners in key categories for the 73rd Golden Globe Awards:
Best film, drama: The Revenant
Best film, musical or comedy: The Martian
Best actor, drama: Leonardo DiCaprio, The Revenant
Best actor, musical or comedy: Matt Damon, The Martian
Best actress, drama: Brie Larson, Room
Best actress, musical or comedy: Jennifer Lawrence, Joy
Best supporting actor: Sylvester Stallone, Creed
Best supporting actress: Kate Winslet, Steve Jobs
Best director: Alejandro Gonzalez Inarritu, The Revenant
Best foreign language film: Son of Saul (Hungary)
Best animated feature: Inside Out
Best drama series: Mr. Robot
Best drama actor: Jon Hamm, Mad Men
Best drama actress: Taraji P Henson, Empire
Best musical or comedy series: Mozart in the Jungle
Best limited series or TV movie actor: Oscar Isaac, Show Me A Hero
Best musical or comedy actor: Gael Garcia Bernal, Mozart in the Jungle
Best musical or comedy actress: Rachel Bloom, Crazy Ex-Girlfriend
Best limited series or TV movie: Wolf Hall
Best limited series or TV movie actress: Lady Gaga, American Horror Story: Hotel
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