According to initial details a US spy plane fired two missiles at a house and a vehicle in Shawal area of North Waziristan.
As a result at least four suspected militants were killed and two others were injured. The identities of those targeted was not immediately clear.
Earlier, in a statement on Monday, the Ministry of Foreign Affairs had termed US drone strikes in Pakistani territory a “clear violation of Pakistan’s sovereignty and territorial integrity,” calling for their immediate cessation.
Read: Drone strikes in North Waziristan a clear violation of Pakistan's sovereignty: FO
On May 16, at least six suspected militants were killed and two others were injured when a US drone fired two missiles at a house in the same area of the agency.
A local source said those killed included foreigners while the house targeted was completely destroyed in the attack.
Read: Drone attack in North Waziristan kills six, injures two suspected militants
According to Bureau Investigates, between 2,449-3,949 people have been killed in 415 drone strikes in Pakistan since 2004. The last strike as recent as April 12, 2015.
Of those killed, between 423-962 were civilians and 172-207 were children.
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