
The attack took place near the Palestinian city of Hebron, not far from a Jewish settlement called Otniel, Israel's Channel 10 said.
"There are two dead," a spokesman for the Magen David Adom ambulance service said.
Tony Blair launches new Middle East peace initiative
There has been a wave of attacks by Palestinians since October 1, with at least 14 Israelis killed in stabbings, shootings and other attacks, including Friday's shooting.
At least 75 Palestinians have been shot dead by Israeli forces, including 45 people who were carrying out or about to carry out attacks.
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