The 29-year-old suspect was detained while driving a van above the speed limit near Tapachula in the state of Chiapas, the US Immigration and Customs Enforcement agency said in a statement.
"The occupants acted erratically, ducking their heads to avoid detection," the statement said.
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"Law enforcement determined the 13 passengers were unlawfully present in Mexico. All were arrested and processed for removal," it said.
The migrants included six Bangladeshi men and one minor and six Pakistani adult males.
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The US immigration agency's Homeland Security Investigations office in Merida, Mexico, worked with Mexican police in the arrest.
Migrants from as far away as Asia and Africa are periodically caught in Mexico while attempting to reach the United States. Their route often begins in South and Central America.
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