
A weakened Chelsea team threw away a 2-0 lead to lose 4-2 at home to third-tier Bradford City in one of the biggest upsets in the competition's recent history, while Premier League champions City lost 2-0 to Championship high-fliers Middlesbrough at the Etihad Stadium.
With Southampton beaten 3-2 by Crystal Palace, it means that none of the Premier League's top three teams will feature in Monday's fifth-round draw, blowing the competition wide open.
Manchester United, who are fourth in the Premier League, face a replay against fourth-division Cambridge United after a 0-0 away draw against the League Two club on Friday.
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