US strikes also hit a separate group of al Qaeda-affiliated militants in northern Syria.
The US military said in a statement it had "destroyed or damaged multiple (Islamic State) targets" around the cities of Raqqa, Deir al-Zor, Hasakah and the border town of Albu Kamal.
“The targets included "(Islamic State) fighters, training compounds, headquarters and command and control facilities, storage facilities, a finance centre, supply trucks and armed vehicles," it said.
The US military said it launched 47 Tomahawk missiles from warships in the Red Sea and North Arabian Gulf, and used remotely piloted and bomber aircraft.
Bahrain, Jordan, Qatar, Saudi Arabia and the United Arab Emirates had "also participated in or supported the air strikes against (Islamic State) targets," it said.
"All aircraft safely exited the strike areas," the US military added.
The Britain-based Syrian Observatory for Human Rights, which monitors the war through a network of sources, said dozens of Islamic State fighters had been wounded or killed in the air strikes.
The group said about 20 air and missile strikes hit IS positions in the city of Raqqa, its western and northern environs, and in and around the towns of Tel Abyad, Tabqa and Ain Issa. It said the governorate building in Raqqa, which IS had been using as its headquarters, was hit.
Another 22 strikes hit IS positions in and around the town of Albu Kamal on the border with Iraq and another eight hit training camps, headquarters, and other positions in the western outskirts of Deir al-Zor city, it said.
The statement from US Central Command said it had also conducted eight strikes against "seasoned al Qaeda veterans" known as "the Khorasan Group" in order to disrupt "imminent attack" by the group who had established safe haven in Syria.
The strikes occurred west of the northern city of Aleppo.
Unlike the strikes against Islamic State which were carried out with allies, those that struck the Khorasan group were "undertaken only by US assets," it said.
The Observatory said three positions of the Nusra Front – al Qaeda's affiliate in Syria - had been hit on the border between Aleppo and Idlib provinces and that at least seven Nusra fighters and eight civilians had been killed.
A Syrian activist confirmed the strikes, saying a house used by Nusra fighters and one of the group's bases had been hit.
In its statement, the US military said it would continue to conduct air strikes in Syria and Iraq - where it said it had conducted 194 air strikes against Islamic State - "as local forces go on the offensive".
US-led strikes kill 30 al Qaeda fighters in Syria: monitor
US-led air strikes killed 30 al Qaeda militants and eight civilians, including children, in northern Syria on Tuesday, the Syrian Observatory for Human Rights said.
Most of the 30 fighters killed in the strikes west of the second city Aleppo were foreigners, and the civilians included three children and one woman, the Britain-based monitoring group said.
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Since the war in Syria is not winniable by the US and the European , they have finally decided to get rid all their citizens (Foreginers) who had gone to fight as holy warriors. This bombing is to get rid of the Dirty Dozen. These fool deserve what tey get.