"Younis will return home on Monday as his nephew Saad Khan died while having a liver transplant in India," a Pakistan Cricket Board spokesperson said.
The 36-year-old Younis made only three in Pakistan's four-wicket win in the first one-day international in Hambantota on Saturday.
Saad's body will reach Pakistan on Monday and will be flown to the family's hometown in Khyber-Pakhtunkhwa, where the funeral will be held.
Pakistan have already lost ace spinner Saeed Ajmal, who will miss the first two one-day internationals to have his suspect bowling action tested in an Australian biomechanics lab.
The PCB spokesperson said no replacement will be sent as lanky paceman Mohammad Irfan is already in Sri Lanka as cover.
Pakistan and Sri Lanka play the second match in Hambantota on Tuesday. The third and final match will be in Dambulla on August 30.
Khan staged a comeback in Pakistan's one-day squad after being dropped in March last year.
He has so far played 254 one-day internationals, having scored 7,017 runs.
COMMENTS (10)
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May Allah rest the soul of that kid and give patience to his family members, also I wonder why Pakistan still not able to develop the liver transplant facility.
My condolences. R.I.P.
Younis Khan, my favorite player in the Pak team, a true ambassador of the game......May God give him and his family the strength and courage to cope with this tragedy.
My sincere condolences
Sorry to hear .... May Allah (SWT) give Younis and his family patient to deal with the tragedy.. Ameen
My condolences with Younis Khan family. May Allah give them strength and patient to deal with this situation
May Allah bless the dead boy
Very sad. God be with you. Take care of your family which is more important than anything.
Condolences. May Allah provide the family strength to bear such a loss.
My condolences to Younis and his family. I hope they will find the strength to deal with this tragedy. As far as the team selection goes, I would have Sharjeel Khan open with Ahmed Shahzad and have M. Hafeez play one down.
Ali Khan Digital Engagement Team, USCENTCOM