Karzai has taken an increasingly antagonistic view of the US role in Afghanistan, despite formerly being a close ally and accepting billions of dollars in aid since he took office after the fall of the Taliban regime in 2001.
The president, who will stand down after elections on April 5, lashed out at the US government and described al Qaeda, the militants behind the 9/11 attacks, as "more a myth than a reality".
"To the American people, give them my best wishes and my gratitude. To the US government, give them my anger, my extreme anger," Karzai told the Washington Post in an interview published on Monday.
There was no immediate response from the US embassy in Kabul, but relations between the two countries have plunged to a new low as the final 55,000 US-led Nato troops prepare to head home and Karzai enters his final months in office.
The president made a surprise decision late last year not to sign an agreed deal that would see 8-12,000 US troops stay in Afghanistan after this year on a training and counter-terrorism mission.
"It's good for them (the US) to sign it with my successor," he said.
In the interview Karzai vented his fury over civilian casualties caused during the war against the Taliban, who had sheltered al Qaeda while in power in Kabul from 1996-2001.
"There is no war to be fought in Afghanistan. I believe that much of the conflict is a creation in which the Afghans suffer," he said.
"Why is America here? I can't answer for America. The American president says they are here to fight extremism and terrorism and to secure America.
"If the way toward securing America is raiding Afghan homes, fighting in Afghan villages - well, that will not secure America."
Among the contenders in the election are Karzai's former foreign minister Zalmai Rassoul, opposition leader Abdullah Abdullah and former World Bank economist Ashraf Ghani.
The new president may not be chosen until after a second-round run-off due on May 28.
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@unbelievable: Dear unbelievable., I will not go into all the murky, and doubtful reasons at to why the US entered into a 13 year war. However, Global Research has estimated that the Bush instigated war has cost $6 trillion, or $75,000 per household. I also will not go into who the nutter is or was, or the rights and wrongs of the Afghan war, but now it is time to go home. Nothing has been seriously accomplished, except for one unidentified body in the Arabian see, and it never will be.
Karzai should prepare the way for Bharatiyah troops to be stationed in Afghanistan for protection, peace and growth.
Karsai reminds me of Pakistan - trying to play both sides of the fence and ending up making enemies of everyone. He's not the only major player in Afghanistan and it's possible that the military or other forces who desperately need the USA and NATO support may decide to rid Afghanistan of this self centered nutter.
@Shafaq:
are you sure about that or US is putting a brave face to cognitive dissonance? friend?
regards,
Surely now Musharaf is smiling.
USA who are you feeling now?.
Surely the hallucination is now coming to an end.
Salute to the brave Soldiers of ISAF + US + Afghans who laid down there lives while combating inside Afghanistan which is now appears to be a lost cause. Sad.
regards,
U.S. had accomplished its assignment and now it doesn't need Mr. Karzai any more.