It is not clear what caused the blast, said authorities, as they investigate whether it was an act of terror or an accident.
The incident took place some 45 kilometres from Karachi where the tankers were loaded with oil before setting off for Afghanistan.
"First a blast took place and then more than nine Nato oil tankers caught fire. We are investigating the cause of the blast," Ahmad Nawaz Cheema, a senior police official in the area, told AFP.
No one was killed or wounded in the incident which took place as the drivers were eating at a roadside hotel after parking the tankers, he added.
Overland oil shipments to Nato troops in landlocked Afghanistan resumed through Pakistan less than two weeks ago under tighter security after a five-month suspension due to attacks.
The contractors had stopped driving oil supplies from Karachi to the Torkham crossing on the Afghan border due to frequent strikes on their vehicles.
On Friday officials said gunmen attacked a convoy of Nato oil tankers, killing a driver and torching eight vehicles.
The Nato combat mission is due to end next year. Pakistan and the United States have signed a deal allowing Nato supply convoys to travel into Afghanistan until the end of 2015.
COMMENTS (3)
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The idiots who burned the tankers don't realize that it is Pakistan and Pakistanis who are paying for these. The US has an agreement with Pakistan that the US will pay Pakistan only after the shipment is received safely. Pakistan has guaranteed safe delivery of the fuel. The tankers belong to Pakistanis owners.
Destroyed by owners themselves to get insurance money...!
PML-N is planning Bullet trains to China in this area......Ha ha