An unmanned aerial combat vehicle struck in the Mir Ali Tehsil of North Waziristan late on Saturday night, killing at least two people, Express News reported.
The drone fired two missiles at two people riding a motorcycle in Mossaki village in Mir Ali.
Local security officials said both the militants were believed to be from Turkmenistan but their exact nationalities are yet to be ascertained.
"The target of the drone was the militants on (the) motorcycle, some nearby houses were also damaged," a local security official told AFP in Miranshah.
Another security official in Miranshah added they were "verifying the reports that both the militants" were from Turkmenistan.
This is the second strike this month.
Earlier in July, a drone had fired missiles on a house in Sarai Darpakhel. The attack destroyed the house and a vehicle parked next to it killing at least 17 people.
The drone attack was the biggest launched this year and the second since Nawaz Sharif took office as prime minister following his victory in May elections.
On June 7, 2013, seven suspected militants were killed and three injured when a drone strike targeted a compound in Mangroti village, in the Shawal tehsil of North Waziristan, according to government officials.