Syrian television broadcast footage of at least four bodies strewn along a main street and firefighters dousing the charred remains of dozens of burning vehicles. Black smoke billowed into the sky.
It said casualties included children at a nearby school in the residential district of the capital. Debris was spread over a wide area.
The windows of Russia's embassy in Damascus were also blown out by the deadly blast but none of its staff were hurt, Russian news agencies reported.
The windows of the embassy were broken and it is currently being assessed if there was further damage, the Interfax and RIA-Novosti news agencies reported, quoting diplomats at the embassy which continued to work normally.
The Syrian Observatory for Human Rights, a Britain-based group which monitors violence in the country, said a car bomb had detonated near a building of the ruling Baath Party. It said cars 300 metres away from the blast were badly damaged.
Activists reported at least two further blasts in the city after the Mazraa explosion, but there were no immediate details.
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Policies gone, people gone ,monuments gone, whats there to fight for now ?
No buildings, no monuments ,no policies, no people whats there to fight for now ?