The blast in Dera Bugti, about 500 kilometres east of Quetta wounded 12 people, but their injuries were not life-threatening, police and local officials said.
Ahmadan Bugti left his shoes outside the mosque while he was offering Friday prayers, provincial home secretary Akbar Durrani told AFP.
Someone planted an explosive device in one of them which detonated as he put the shoe back on.
"Bugti's leg was badly wounded, a helicopter has been arranged to fly him to Quetta," Durrani said.
There was no immediate claim of responsibility.
Correction: An earlier version of this article had incorrectly stated that Bugti is a PPP MNA. The error has been corrected.
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Now this Bugti was against Azad Balochistan...Who else could b behind this, other than the BLA/BLF Terrorists..!