The settlement includes $1 billion in criminal fines and $2 billion in civil fines in connection with the sale of the drug company's Paxil, Wellbutrin and Avandia products.
Deputy US Attorney General James Cole said on Monday that the settlement "is unprecedented in both size and scope."
As part of the settlement, GlaxoSmithKline agreed to strict oversight of its sales force by the US government to prevent the use of kickbacks or other prohibited practices.
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America they name is fraud