Pakistan were 90 for six, a deficit of 264, at tea.
Shoaib Malik is at 26 and Mohammad Aamer is 22 not out.
James Anderson struck with three wickets as Pakistans top order crumbled.
Mohammad Asif took five wickets for 77 runs as England lost their last six wickets for 17 runs in 51 balls.
England finished day 1 at 331 runs for the loss of 4 wickets.
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