The 58-year-old woman gets so anxious she has to take treatment for a life-threatening condition brought on by watching knife-edge games at the Old Trafford stadium.
The condition, known as an Addisonian crisis, comes about when the adrenal glands do not produce enough of the stress-reducing hormone cortisol, a lack of which can lead to low blood pressure and even a coma.
"We believe that our patient was having difficulty mounting an appropriate physiological cortisol response during the big games and therefore we present this as the first description of Manchester United-induced Addisonian crisis," said Dr Akbar Choudhry who treated the patient.
Doctors suspected the condition when the woman started getting bouts of anxiety, palpitations, panic, light headedness, and a sense of impending doom towards the end of matches.
The symptoms were less serious when the home side was playing a lower-rated team.
An Addisonian crisis, which is a manifestation of Addison's disease, is difficult to diagnose because the main symptoms include fatigue, lethargy and low mood -- often experienced by otherwise healthy people and frequently reported in many other chronic conditions.
"Luckily, the patient was on holiday for United's 6-1 defeat by local rivals Manchester City in October," Choudhry said in a report on BMJ.com.
"But, by this time, doctors had fine-tuned her therapy and she has remained symptom-free during recent tense contests against Sunderland and FC Basel," he added.
Treatment coincided with the start of the 2011/12 football season and the patient has managed to attend all games at Old Trafford without any adverse effects.
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