UN chief Antonio Guterres urged the world to "rev up the engine of development" at an aid conference on Monday as US-led cuts jeopardise the fight against poverty and climate change.
Dozens of world leaders and more than 4,000 representatives from businesses, civil society and financial institutions are in the Spanish city of Seville for the June 30-July 3 meeting to seek fresh impetus for the crisis-hit sector.
But the United States is snubbing the biggest aid talks in a decade, underlining the erosion of international cooperation on combating hunger, disease and climate change.
Guterres told the opening of the conference that two-thirds of UN sustainable development goals set for 2030 were "lagging" and more than $4 trillion of annual investment were needed to achieve them.
President Donald Trump's gutting of US development agency USAID is the standout example of aid cuts, but Germany, Britain and France have also slashed funds while boosting spending in defence and other areas.
The Oxfam charity says the cuts are the largest since 1960, while according to the World Bank rising extreme poverty is affecting sub-Saharan Africa in particular.
Disruption to global trade from Trump's tariffs and conflicts in the Middle East and Ukraine have dealt further blows to the diplomatic cohesion necessary for concentrating efforts on helping countries escape poverty.
The crisis meant children going unvaccinated, girls dropping out of school and families suffering hunger, said Guterres. He urged nations to "change course" and "repair and rev up the engine of development to accelerate investment" in "a world shaken by inequalities, climate chaos and raging conflicts".
A blistering heatwave that is scorching southern Europe welcomed delegates, an example of the extreme weather that scientists say human-driven climate change is fuelling.
Spain's Prime Minister Pedro Sanchez said it was "time to take a step forward and not only reaffirm our commitment, but also redouble it".
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