The main issue discussed was the ongoing War Against Terrorism.
Clinton discussed Pakistan's future course of action in dealing with the growing terror threat in Pakistan.
She said that there still remained a large number of al-Qaeda members in the country who pose a serious threat not only to Pakistan, but also to the United States.
Clinton added that the US appreciates Pakistan's efforts in combating terrorism.
She added that CIA Chief Leon Panetta will soon be visiting Pakistan.
The phone call comes as Diplomatic ties between Pakistan and the United States improve following last months Abbottabad Operation.
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