
United's build-up to the new campaign has been dominated by manager Jose Mourinho's persistent grumbles over the strength of his squad.
Unlike most of Mourinho's stars, Sanchez had a first full summer off in nine years as Chile failed to qualify for the World Cup, ensuring he should be fresh enough to show why United handed him a contract reportedly worth a potential £25 million a year in January.
In his first six months at Old Trafford, Sanchez was a pale imitation of the player who dazzled at Arsenal.
The Chilean scored just three times in 18 games as United ended the season without a trophy. Despite finishing second in the Premier League they were a painful 19 points adrift of local rivals Manchester City.
Mourinho warns of difficult season ahead
Mourinho has bemoaned United's lack of transfer activity, criticised captain Antonio Valencia's physical condition and been involved in a standoff with Anthony Martial over the length of the Frenchman's absence to attend the birth of his second child.
But at least Sanchez has given him cause for optimism, scoring against Real Madrid and AC Milan in glamour friendlies, showing the drive, determination and decisiveness of old.
Mourinho even defended Sanchez after the forward cut a frustrated figure in Manchester United's 4-1 defeat by Liverpool in a friendly in the US.
The manager made withering comments on the standard of United's youngsters that contrasted starkly with the encouraging words City boss Pep Guardiola and Liverpool manager Jurgen Klopp have had for their own young players.
"Do you want him to be very happy with the players he has around him?" said Mourinho. "Alexis is the only attacking player we have. We don't have wingers, we don't have strikers. He's the only one who is here, and the poor man is there trying his best, with the frustration of somebody that wants more."
Romelu Lukaku and Marcus Rashford have since returned from their World Cup exertions but both are unlikely to be fit enough for 90 minutes against Leicester, possibly leaving Sanchez as the focal point of United's attack.
World Cup winner Paul Pogba is also unlikely to be fit for the game at Old Trafford.
From his first weeks in Manchester, Mourinho insisted Sanchez's struggles would be forgotten when he hit the ground running after a full pre-season under his belt.
"I think this was a chance that we didn't want to lose and we made it. But we don't believe a lot in the winter market and for sure next season it will be better for him," Mourinho said after beating City to his signature. "Next season, after pre-season, after being comfortable and adapted, he's going to be great for us."
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