According to police sources, the officer's convoy was on its way back from Kolachi area when the explosives planted on the road went off.
A senior police official said the DPO was the apparent target of the terrorist attack.
On March 24, 24 people were injured after a hand grenade was hurled towards the stage of a spring festival event in DI Khan.
Hand grenade attack: 24 injured at spring festival in DI Khan
The incident took place in the Sikandar village where eyewitnesses confirmed that the hand grenade was thrown from behind the stage.
Last month, 80 people were arrested in the city after a mob belonging to Ahmadzai Wazir tribe, set ablaze offices of Aman Lashkar.
The crowd set offices of the group and two cars in Madina Colony on fire to protest the murder of a young man allegedly by a member of the lashkar.
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