CIA Director Leon Panetta and US National Security Adviser James Jones met with President Zardari.
The meeting was held at the Presidency in Islamabad on Wednesday.
Army Chief Ashfaq Pervaiz Kayani and Prime Minister Gilani also attended the meeting.
Discussions focused on the failed Times Square bombing and the tribal regions where the suspect is alleged to have received training.
It was the first high-level trip since the May 1 failed car bomb attack at Times Square.
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